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The following is a summary of “Neutrophil extracellular traps promote ?Np63+ basal cell hyperplasia in chronic rhinosinusitis,” published in the March 2024 issue of Allergy & Immunology by Lim, et al.
Neutrophil extracellular traps (NETs) are observed in chronic rhinosinusitis (CRS), yet their role remains uncertain. For a study, researchers sought to investigate the influence of NETs on the CRS epithelium.
Sinonasal biopsy specimens from 45 individuals were immunofluorescence-stained to identify NETs and p63+ basal stem cells. Human nasal epithelial cells were treated with NETs, and their response was assessed using immunofluorescence staining, Western blotting, and quantitative real-time PCR. NET inhibitors were administered in a murine neutrophilic nasal polyp model.
NETs were present in CRS tissues, particularly in non-eosinophilic nasal polyp tissues, and exhibited a positive correlation with p63+ basal cell expression. NETs induced the expansion of Ki-67+p63+ cells. The isoform ?Np63, predominantly expressed in the nasal epithelium, was regulated by NETs. Treatment with deoxyribonuclease (DNase) I or Sivelestat (NET inhibitors) mitigated the overexpression of ?Np63+ epithelial stem cells and reduced polyp formation.
The findings suggested that NETs contribute to CRS pathogenesis through basal cell hyperplasia. Targeting NETs may offer a novel approach for treating CRS.
Reference: jacionline.org/article/S0091-6749(23)01478-1/abstract
The post Pathogenic Mechanism Reveals NETs Drive ?Np63+ Basal Cell Hyperplasia in CRS first appeared on Physician’s Weekly.
